Thermo Fisher Scientific LASS4 Monoclonal Antibody (7D5)
LASS4 단백질을 인식하는 Mouse monoclonal antibody (clone 7D5). Western blot, ICC/IF, ELISA에 적합. Human 시료 반응성. Affinity chromatography로 정제된 액상형 항체로, PBS buffer에 보존제 없이 제공. 연구용 전용 시약.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 0.3 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 7D5 |
| Immunogen | LASS4 (NP_078828, 57 a.a. to approximately 139 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 kDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein sequence:
ERFIGLPLSR WLGVRDQTRR QVKPNATLEK HFLTEGHRPK EPQLSLLAAQ CGLTLQQTQR WFRRRRNQDR PQLTKKFCEA SWR
Target Information
The LASS (longevity assurance homolog) family members are highly conserved from yeasts to mammals. Six members of this family (LASS1–LASS6) are involved in sphingolipid synthesis.
LASS4 is a 394 amino acid endoplasmic reticulum multi-pass membrane protein that increases levels of long ceramides such as C22:0 and C24:0.
In CLN9-deficient cells, as seen in neuronal ceroid lipofuscinosis (NCL, Batten disease), LASS4 can elevate ceramide levels and partially correct growth and apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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