Thermo Fisher Scientific PHKG2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.04–0.4 µg/mL

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
LTAEQALQHP FFERCEGSQP WNLTPRQRFR VAVWTVLAAG RVALSTHRVR PLTKNALLRD PYALRSVRHL IDNCAFRLY

Target Information

PHKG2 is a testis/liver isoform of the phosphorylase kinase gamma subunit. Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma, and delta. The alpha subunit includes skeletal muscle and hepatic isoforms encoded by two different genes. The beta subunit is common to both isoforms and encoded by one gene. The gamma subunit includes skeletal muscle and hepatic isoforms, with the hepatic isoform encoded by PHKG2. The delta subunit is a calmodulin encoded by three different genes. Gamma subunits contain the enzyme's active site, while alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates calcium dependence. Mutations in PHKG2 cause glycogen storage disease type 9C (autosomal liver glycogenosis). Alternatively spliced transcript variants encoding different isoforms have been identified in PHKG2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.