Thermo Fisher Scientific Bestrophin 1 Polyclonal Antibody
Bestrophin 1 단백질을 검출하기 위한 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간 및 생쥐 반응성, WB 및 ELISA에 적합. 고순도 친화 크로마토그래피 정제, 액상 형태로 안정적 저장 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 376–585 of human BEST1 (NP_004174.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805682 |
Product Specific Information
Immunogen sequence:
QPNQEDEEDA HAGIIGRFLG LQSHDHHPPR ANSRTKLLWP KRESLLHEGL PKNHKAAKQN VRGQEDNKAW KLKAVDAFKS APLYQRPGYY SAPQTPLSPT PMFFPLEPSA PSKLHSVTGI DTKDKSLKTV SSGAKKSFEL LSESDGALME HPEVSQVRRK TVEFNLTDMP EIPENHLKEP LEQSPTNIHT TLKDHMDPYW ALENRDEAHS
Positive Samples: Mouse liver, Mouse lung
Cellular Location: Basolateral cell membrane, Cell membrane, Multi-pass membrane protein
Target Information
The retinal pigment epithelium (RPE) and choroid form a differentiated system essential for retinal health and function.
Best vitelliform macular dystrophy (Best disease) is an early-onset autosomal dominant disorder characterized by accumulation of lipofuscin-like material within and beneath the RPE, leading to progressive central vision loss.
Mutations in the Bestrophin gene cause this condition by disrupting the function of Bestrophin, a protein localized to the basolateral plasma membrane of RPE cells.
Human Bestrophin forms oligomeric chloride channels sensitive to intracellular calcium, and missense mutations can reduce or abolish membrane current.
The human Bestrophin gene encodes a 585 amino acid protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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