Thermo Fisher Scientific ZRANB3 Polyclonal Antibody
Thermo Fisher Scientific의 ZRANB3 Polyclonal Antibody는 인간 ZRANB3 단백질을 인식하는 토끼 IgG 항체로, Western blot에 적합합니다. 합성 펩타이드 면역원 기반으로 제작되었으며, 액상 형태로 −20°C에서 보관합니다. 유전체 안정성 연구에 활용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1.0 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the C-terminal region of human ZRANB3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2690397 |
Product Specific Information
This target displays homology in the following species:
Cow: 86%; Dog: 93%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 100%; Rat: 100%
Target Information
ZRANB3 is a DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks. It facilitates fork restart and limits inappropriate recombination during template switching events (PubMed:21078962, 22704558, 22705370, 22759634, 26884333).
Recruited by polyubiquitinated PCNA to stalled replication sites, ZRANB3 acts as a structure-specific endonuclease that cleaves replication fork D-loop intermediates, generating a 3'-OH group suitable for DNA polymerase extension.
Additionally, ZRANB3 catalyzes fork regression via annealing helicase activity to prevent replication fork disintegration and double-strand break formation (PubMed:22705370, 22704558). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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