Thermo Fisher Scientific DTX2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.3 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

5 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide with sequence C-EKLSTASGYSDVTD (aa 417-430). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:DTX2,uniProtId:Q86UW9-1,ncbiNodeId:9606,antigenRange:417-430,antigenLength:622,antigenImageFileName:PA5-142519_DTX2_Q86UW9-1_Goat.svg,antigenImageFileNamePDP:PA5-142519_DTX2_Q86UW9-1_Goat_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Ammonium sulfate precipitation

Storage buffer

TBS, pH 7.3, with 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2933166

Product Specific Information

Additional Information: This antibody is expected to recognize both reported isoforms (NP_065943.2; NP_001096066.1).

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.

Target Information

DTX2 functions as an E3 ubiquitin ligase. Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.