Thermo Fisher Scientific PSMB7 Monoclonal Antibody (OTI4E3), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The proteasome is a multicatalytic proteinase complex with a highly ordered 20S core structure composed of four rings of 28 non-identical subunits (two α and two β rings). Proteasomes degrade peptides in an ATP/ubiquitin-dependent, non-lysosomal pathway.
The PSMB7 gene encodes a β subunit of the 20S proteasome core, part of the proteasome B-type (T1B) family. Its expression is downregulated by gamma interferon, and proteolytic processing is necessary for maturation. This subunit is absent in the immunoproteasome, where it is replaced by catalytic subunit 2i (proteasome β10 subunit).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.