Thermo Fisher Scientific Talizumab Chimeric Recombinant Human Monoclonal Antibody

Applications

• ELISA (ELISA): Assay-dependent

Product Specifications

Product Specific Information

• Endotoxin level < 0.01 EU/µg by LAL method
• Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
• Store at 2–8°C for one week.
• Store at -20 to -80°C for twelve months from the date of receipt.

Target Information

Talizumab is a biosimilar that targets IgE.
IgE is one of the five classes of immunoglobulins found in mammals. Monomers consist of two heavy (epsilon) chains with four Ig-like constant domains and two light chains.
IgE plays an essential role in type I hypersensitivity (allergic responses such as hay fever, asthma, hives, and anaphylactic shock) by binding to Fc receptors on basophils and mast cells. Crosslinking of IgE bound to Fc receptors induces degranulation of mast cells and basophils, promoting allergic manifestations.
IgE is also functionally important for immunity against parasites.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.