ELK Biotechnology Amyloid-β rabbit pAb
Amyloid-β rabbit polyclonal antibody for detection of APP and related peptides. Suitable for WB, IHC, IF, and ELISA. Recognizes human APP peptide (AA 711–760). Provides reliable detection of amyloid-related proteins in Alzheimer’s research.
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ELK Biotechnology Amyloid-β rabbit pAb
제품 개요
Amyloid-β rabbit polyclonal antibody는 인간 APP 유래 합성 펩타이드(AA range: 711–760)를 면역원으로 제작된 항체로, 알츠하이머병 관련 단백질 연구에 사용됩니다. 다양한 응용 분야(WB, IHC, IF, ELISA)에서 높은 특이성과 재현성을 제공합니다.
제품 사양
| 항목 | 내용 |
|---|---|
| Product Name | Amyloid-β rabbit pAb |
| Alternative Names | APP; A4; AD1; Amyloid beta A4 protein; ABPP; APPI; APP; Alzheimer disease amyloid protein; Cerebral vascular amyloid peptide; CVAP; PreA4; Protease nexin-II; PN-II |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 IF: 1/200–1/1000 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human APP (AA 711–760) |
| Host | Rabbit |
| Storage | −20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 117 kDa |
| GeneID (Human) | 351 |
| Human Swiss-Prot No. | P05067 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치 (Cellular Localization)
- Cell membrane; Single-pass type I membrane protein
- Membrane; Single-pass type I membrane protein
- Perikaryon; Cell projection, growth cone
- Membrane, clathrin-coated pit; Early endosome; Cytoplasmic vesicle
- Cell surface protein that rapidly becomes internalized via clathrin-coated pits.
- Most of the protein is present in intracellular vesicles (PubMed:20580937).
- During maturation, immature APP moves to the Golgi complex for complete maturation (O-glycosylation and sulfation).
- After alpha-secretase cleavage, soluble APP is released into the extracellular space, and the C-terminal fragment is internalized to endosomes and lysosomes.
- Some APP accumulates in secretory transport vesicles.
배경 정보 (Background)
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form various peptides. Some peptides bind to the APBB1/TIP60 complex to promote transcriptional activation, while others form amyloid plaques characteristic of Alzheimer’s disease. Certain peptides exhibit antimicrobial properties. Mutations are associated with autosomal dominant Alzheimer’s disease and cerebral amyloid angiopathy. Multiple transcript variants and isoforms have been identified.
[provided by RefSeq, Aug 2014]
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