ELK Biotechnology Abl1/2 rabbit pAb
Abl1/2 rabbit polyclonal antibody는 인간 및 마우스 시료에 반응하며, WB, IHC, IF, ELISA에 적합합니다. 인간 c-Abl 유래 합성 펩타이드로 면역화되었으며, 세포질, 핵, 미토콘드리아 등 다양한 세포소기관에 위치한 단백질 검출에 유용합니다.
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제품명
Abl1/2 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | ABL1; ABL; JTK7; Tyrosine-protein kinase ABL1; Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Proto-oncogene c-Abl; p150; ABL2; ABLL; ARG; Abelson tyrosine-protein kinase 2; Abelson murine leukemia viral oncogene homolog 2 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000; Immunohistochemistry: 1/100 - 1/300; ELISA: 1/20000; Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human c-Abl (AA range: 406–455) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 125 kDa (200 kDa BCR-ABL complex) |
| Gene ID (Human) | 25 / 27 |
| Human Swiss-Prot No. | P00519 / P42684 |
| Species Reactivity | Human; Mouse |
| Cellular Localization | Cytoplasm, cytoskeleton, nucleus, mitochondrion. Shuttles between nucleus and cytoplasm depending on environmental signals. Sequestered into cytoplasm through interaction with 14-3-3 proteins. Localizes to mitochondria under oxidative stress. Isoform IB: nucleus membrane, lipid-anchor. The myristoylated c-ABL protein is reported to be nuclear. |
Background
This gene is a proto-oncogene encoding a protein tyrosine kinase involved in cell division, adhesion, differentiation, and stress response. The SH3 domain negatively regulates its activity; deletion of this domain results in oncogenic transformation. The protein exhibits DNA-binding activity regulated by CDC2-mediated phosphorylation, suggesting a role in the cell cycle. The gene is known to fuse with various translocation partner genes in leukemias, notably the t(9;22) translocation forming the BCR-ABL fusion. Alternative splicing results in two transcript variants with different first exons spliced to common exons.
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