ELK Biotechnology ERK 1/2 (phospho Thr202/Y204) rabbit pAb
ERK 1/2 (phospho Thr202/Y204) rabbit polyclonal antibody로 MAPK 신호전달 경로 연구에 적합. IF, WB, IHC, ELISA 등 다양한 응용 가능. 인산화된 ERK1/2 검출에 특이적. 고순도 IgG, -20°C에서 1년 보관 가능.
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제품명
ERK 1/2 (phospho Thr202/Y204) rabbit pAb
제품 개요
이 항체는 인산화된 ERK1/2 (Thr202/Y204) 부위를 인식하는 rabbit polyclonal antibody로, MAP kinase 신호전달 경로 연구 및 세포 내 신호 조절 분석에 유용합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product Name | ERK 1/2 (phospho Thr202/Y204) rabbit pAb |
| Alternative Names | MAPK3; ERK1; PRKM3; Mitogen-activated protein kinase 3; MAP kinase 3; MAPK 3; ERT2; Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 kinase |
| Applications | IF; WB; IHC; ELISA |
| Recommended Dilutions | IF: 1:50–200 WB: 1:500–1:2000 IHC: 1:100–1:300 ELISA: 1:20000 Not yet tested in other applications |
| Immunogen | Synthesized phospho-peptide around the phosphorylation site of human ERK 1/2 (phospho Thr202/Y204) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 5595 / 5594 |
| Human Swiss-Prot No. | P27361 / P28482 |
| Cellular Localization | Cytoplasm, Nucleus, Membrane (caveola), Cell junction (focal adhesion). Autophosphorylation at Thr-207 promotes nuclear localization (PubMed:19060905). PEA15-binding redirects MAPK3 signaling by sequestering MAPK3 into the cytoplasm (By similarity). |
| Species Reactivity | Human; Mouse; Rat; Fish |
Background
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described.
[Provided by RefSeq, Jul 2008]
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