ELK Biotechnology Adducin α/β (phospho Ser726/713) rabbit pAb
Adducin α/β 인산화(Ser726/713) 부위를 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간, 마우스, 랫트 반응성. 세포막 및 세포골격 단백질 연구에 적합. -20°C에서 1년 보관.
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Adducin α/β (phospho Ser726/713) Rabbit Polyclonal Antibody
제품 정보
| 항목 | 내용 |
|---|---|
| Product Name | Adducin α/β (phospho Ser726/713) rabbit pAb |
| Alternative Names | ADD1; ADDA; Alpha-adducin; Erythrocyte adducin subunit alpha; ADD2; ADDB; Beta-adducin; Erythrocyte adducin subunit beta |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 IF: 1/200–1/1000 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human ADD1 around the phosphorylation site of Ser726 (AA range: 688–737) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 80 kDa |
| Gene ID (Human) | 118 / 119 |
| Human Swiss-Prot No. | P35611 / P35612 |
| Cellular Localization | Cytoplasm, cytoskeleton; Cell membrane (Peripheral membrane protein, cytoplasmic side) |
| Species Reactivity | Human; Mouse; Rat |
Background
Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, gamma). These heterodimeric proteins consist of related subunits produced from distinct genes but sharing similar structures. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed, while beta-adducin is highly expressed in brain and hematopoietic tissues. Adducin binds with high affinity to Ca²⁺/calmodulin and serves as a substrate for protein kinases A and C. Alternative splicing results in multiple isoforms, though not all variants are fully characterized. (RefSeq, Jul 2008)
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