ELK Biotechnology JNK1/2/3 (phospho Tyr185) rabbit pAb
JNK1/2/3 (phospho Tyr185) rabbit pAb는 MAP kinase family의 인산화된 형태를 검출하는 다클론 항체입니다. IF, WB, IHC, ELISA 등 다양한 응용에 적합하며, 인간, 마우스, 랫트 시료에서 반응합니다. 세포 내 신호전달 및 아폽토시스 연구에 활용됩니다.
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제품명
JNK1/2/3 (phospho Tyr185) rabbit pAb
공급업체
ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | MAPK8; JNK1; PRKM8; SAPK1; SAPK1C; Mitogen-activated protein kinase 8; MAP kinase 8; MAPK 8; JNK-46; Stress-activated protein kinase 1c; SAPK1c; Stress-activated protein kinase JNK1; c-Jun N-terminal kinase 1; MAPK9; JNK2; PRKM9; SAPK1A; Mi |
| Applications | IF; WB; IHC; ELISA |
| Recommended Dilutions | IF: 1:50–200 Western Blot: 1:500–1:2000 Immunohistochemistry: 1:100–1:300 ELISA: 1:20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human SAPK/JNK around phosphorylation site Tyr185 (AA range: 151–200) |
| Host | Rabbit |
| Storage | −20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 45 kD |
| GeneID (Human) | 5599 / 5601 / 5602 |
| Human Swiss-Prot No | P45983 / P45984 / P53779 |
| Cellular Localization | Cytoplasm, Nucleus, Cell junction, Synapse. In cortical neurons, predominantly cytoplasmic and associated with Golgi apparatus and endosomal fraction. Increased neuronal activity increases phosphorylated form at synapses. Colocalizes with POU5F1 in nucleus. |
| Species Reactivity | Human; Mouse; Rat |
Background
The protein encoded by this gene belongs to the MAP kinase family, which integrates multiple biochemical signals and regulates cellular processes such as proliferation, differentiation, transcription, and development. It is activated by various stimuli and mediates immediate-early gene expression through transcription factor targeting. Activation by TNF-alpha is required for TNF-alpha–induced apoptosis and is also involved in UV radiation–induced apoptosis related to cytochrome c–mediated pathways. Mouse studies suggest a key role in T cell proliferation, apoptosis, and differentiation. Several alternatively spliced variants exist.
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