ELK Biotechnology FRS2 (phospho Tyr436) rabbit pAb
FRS2 (phospho Tyr436) rabbit pAb는 인간 FRS2의 Tyr436 인산화 부위를 인식하는 폴리클로날 항체입니다. WB, IHC, IF, ELISA에 적합하며, 세포 내 신호전달 연구에 활용됩니다. 고순도 IgG 형태로 -20°C에서 1년간 안정적으로 보관 가능합니다.
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제품명
FRS2 (phospho Tyr436) rabbit pAb
공급업체
ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | FRS2; Fibroblast growth factor receptor substrate 2; FGFR substrate 2; FGFR-signaling adaptor SNT; Suc1-associated neurotrophic factor target 1; SNT-1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human FRS2 around the phosphorylation site of Tyr436 (AA range: 402–451) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 65 kD |
| GeneID (Human) | 10818 |
| Human Swiss-Prot No | Q8WU20 |
| Cellular Localization | Endomembrane system; Cytoplasmic, membrane-bound |
| Species Reactivity | Human; Mouse; Monkey |
Background
Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
Phosphorylated on tyrosine residues upon stimulation by NGF. Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2; the unphosphorylated form is not subject to ubiquitination.
Contains 1 IRS-type PTB domain. Cytoplasmic, membrane-bound localization.
Part of a complex containing FRS2, GRB2, and SOS1; also interacts with GRB2 and CBL. Binds RET, FGFR1, SUC1, NTRK1, NTRK2, NTRK3, and SRC.
Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney, and testis.
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