ELK Biotechnology p38 (phospho Tyr323) rabbit pAb
p38 (phospho Tyr323) rabbit pAb는 인산화된 p38 MAPK를 인식하는 폴리클로날 항체로, IF, WB, IHC, ELISA에 적합합니다. 인간, 마우스, 랫트에 반응하며 세포 스트레스 및 신호전달 연구에 활용됩니다. -20°C에서 1년 보관 가능합니다.
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제품명
p38 (phospho Tyr323) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | MAPK14; CSBP; CSBP1; CSBP2; CSPB1; MXI2; SAPK2A; Mitogen-activated protein kinase 14; MAP kinase 14; MAPK 14; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAP kinase MXI2; MAX-interacting protein |
| Applications | IF; WB; IHC; ELISA |
| Recommended Dilutions | IF: 1:50–200; Western Blot: 1:500–1:2000; IHC: 1:100–1:300; ELISA: 1:5000; Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human p38 MAPK around the phosphorylation site of Tyr322 (AA range: 288–337) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 38 kD |
| Gene ID (Human) | 1432 |
| Human Swiss-Prot No. | Q16539 |
| Cellular Localization | Cytoplasm, Nucleus |
| Species Reactivity | Human, Mouse, Rat |
Background
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals and are involved in various cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is activated by environmental stresses and proinflammatory cytokines, requiring phosphorylation by MAP kinase kinases (MKKs) or autophosphorylation triggered by interaction with MAP3K7IP1/TAB1. Its substrates include transcription regulators (ATF2, MEF2C, MAX), cell cycle regulator CDC25B, and tumor suppressor p53, indicating roles in stress-related transcription, cell cycle regulation, and genotoxic stress response. Four alternatively spliced transcript variants have been identified.
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