ELK Biotechnology PLC γ1 (phospho Tyr771) rabbit pAb
PLCγ1 (phospho Tyr771) rabbit polyclonal antibody로, 인산화 Tyr771 부위에 특이적으로 반응합니다. WB, IHC, IF, ELISA에 사용 가능하며, 인간, 마우스, 랫드, 원숭이에 반응합니다. 세포 신호전달 연구에 적합한 고품질 항체입니다.
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PLC γ1 (phospho Tyr771) rabbit pAb
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| 항목 | 내용 |
|---|---|
| Alternative Names | PLCG1; PLC1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; PLC-148; Phosphoinositide phospholipase C-gamma-1; Phospholipase C-II; PLC-II; Phospholipase C-gamma-1; PLC-gamma-1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human PLCG1 around phosphorylation site of Tyr771 (AA range: 736–785) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 150 kD |
| Gene ID (Human) | 5335 |
| Human Swiss-Prot No. | P19174 |
| Species Reactivity | Human; Mouse; Rat; Monkey |
| Cellular Localization | Cell projection, lamellipodium, ruffle. Rapidly redistributed to ruffles and lamellipodia structures in response to EGF treatment. |
Background
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in intracellular transduction of receptor-mediated tyrosine kinase activators. When activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. It is also a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been identified for this gene (RefSeq, Jul 2008).
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