ELK Biotechnology Caspase-9 (phospho Thr125) rabbit pAb
Caspase-9 (phospho Thr125) rabbit pAb는 인산화된 Caspase-9 단백질을 특이적으로 인식하는 폴리클로날 항체로, 세포사멸 연구에 적합합니다. WB, IHC, IF, ELISA 등 다양한 응용에 사용 가능하며, 인간, 생쥐, 랫드 시료에 반응합니다.
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Caspase-9 (phospho Thr125) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Caspase-9 (phospho Thr125) rabbit pAb |
| Alternative Names | CASP9; MCH6; Caspase-9; CASP-9; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; APAF-3; ICE-like apoptotic protease 6; ICE-LAP6 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Caspase 9 around the phosphorylation site of Thr125. AA range: 91–140 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 46 kD |
| Gene ID (Human) | 842 |
| Human Swiss-Prot No. | P55211 |
| Cellular Localization | Nucleus, mitochondrion, cytosol, apoptosome |
| Species Reactivity | Human, Mouse, Rat |
Background
CASP9 encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, which dimerize to form the active enzyme. Caspase-9 can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1. This step is thought to be one of the earliest in the caspase activation cascade. Caspase-9 plays a central role in apoptosis and is considered a tumor suppressor. Alternative splicing results in multiple transcript variants.
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