Thermo Fisher Scientific Human ATOH8 Synthetic Peptide

Thermo Fisher Scientific Human ATOH8 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 15 amino acids near the carboxy terminus of human ATOH8.
PEP-0825 can be used as a blocking peptide with polyclonal antibody PA5-20710.

Target Information

Basic helix-loop-helix (bHLH) transcription factors play important roles in differentiation processes during embryonic development of vertebrates.
ATOH8 (MATH6) is a tissue-restricted member of the atonal superfamily of bHLH transcription factors that exhibits 43–57% identity in the bHLH domain with other mammalian atonal paralogs, including NeuroD and Neurogenin factors.
In the mouse, ATOH8 has been implicated in the specification and differentiation of neuronal cell lineages in the brain and may also participate in kidney development.
Recent studies show that ATOH8 is a novel component of the pancreatic transcriptional network during embryonic development and suggest a potential role as a modulator of the differentiation program initiated by the pro-endocrine factor Neurog3.
It is indispensable for early embryonic development, suggesting a more widespread function for this factor in tissue-specific differentiation processes dependent on class II bHLH genes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.