Thermo Fisher Scientific HIP1R Polyclonal Antibody
HIP1R 단백질을 인식하는 Thermo Fisher의 토끼 폴리클로날 항체. Western blot, IHC(P), ICC/IF에 사용 가능. 인간 시료 반응성. 항원 친화 크로마토그래피로 정제. 신경퇴행성 질환 및 암 연구용으로 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:2,500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human HIP1R. Recombinant protein control fragment (Product #RP-102810) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642441 |
Product Specific Information
Immunogen sequence:
VVADLFDQTF GPPNGSVKDD RDLQIESLKR EVEMLRSELE KIKLEAQRYI AQLKSQVNAL EGELEEQRKQ KQKALVDNEQ LR
Sequence identity:
- Mouse: 89%
- Rat: 89%
Target Information
Huntingtin disease, a neurodegenerative disorder, is caused by the expansion of a polymorphic glutamine tract in huntingtin. The Huntingtin Interacting Protein 1 (HIP-1) is a proapoptotic, cargo-specific adaptor protein that may be involved in the pathogenesis of Huntingtin disease. It also participates in clathrin coat recruitment to lipid membranes and may play a role in tumorigenesis by supporting survival of precancerous and cancerous cells. HIP-1 expression is significantly associated with prostate and colon cancer metastasis, making it a putative prognostic factor for these cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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