Thermo Fisher Scientific Human Epiregulin Recombinant Protein, PeproTech
인체 유래 Epiregulin 재조합 단백질로, EGF 관련 성장인자 연구에 적합합니다. 고순도(≥98%) 및 낮은 엔도톡신(<1 EU/µg)을 보장하며, 세포 증식 활성 검증 완료. Lyophilized 형태로 -20°C 보관, 연구용 전용 제품입니다.
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Applications
Functional Assay (Functional)
- Assay-dependent
In vitro Assay (IV)
- Tested in vitro
- View 7 publications
Miscellaneous PubMed (Misc)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Published Species | Human, Mouse |
| Expression System | E. coli |
| Amino Acid Sequence | MVAQVSITKC SSDMNGYCLH GQCIYLVDMS QNYCRCEVGY TGVRCEHFFL |
| Molecular Weight | 5.6 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 98% by SDS-PAGE gel and HPLC analyses |
| Endotoxin Concentration | <1 EU/µg |
| Activity | ED50 ≤ 2.0 ng/ml (specific activity ≥ 5 × 10⁵ units/mg) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
Product Specific Information
Recombinant Human Epiregulin is a 5.6 kDa monomeric protein containing 50 amino acid residues, corresponding to the mature secreted Epiregulin sequence.
This product is shipped at ambient temperature. For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis.
Target Information
Epiregulin is an EGF-related growth factor that binds specifically to EGFR (ErbB1) and ErbB4, but not to ErbB2 or ErbB3.
It is mainly expressed in the placenta and peripheral blood leukocytes, as well as in certain carcinomas of the bladder, lung, kidney, and colon.
Epiregulin stimulates the proliferation of keratinocytes, hepatocytes, fibroblasts, and vascular smooth muscle cells, while inhibiting the growth of several tumor-derived epithelial cell lines.
Human Epiregulin is initially synthesized as a glycosylated 19.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a 6.0 kDa mature secreted sequence.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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