Thermo Fisher Scientific GPR68 Polyclonal Antibody
GPR68 단백질을 인식하는 Rabbit Polyclonal 항체로, 다양한 종에 반응합니다. IHC(P)에서 검증되었으며, 항원 친화 크로마토그래피로 정제되었습니다. pH 감지 수용체 연구 및 암 관련 연구에 유용합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 6 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Dog, Horse, Hamster, Human, Mouse, Non-human primate, Pig, Rabbit, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human GPR68 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551127 |
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Dog, Bovine, Hamster, Panda, Horse, Rabbit, Pig (100%).
Target Information
GPR68 (also known as OGR1 - ovarian cancer G-protein coupled receptor 1) is a proton-sensing receptor involved in pH homeostasis. It functions as an osteoblastic pH sensor regulating the cell-mediated response to acidosis in bone. GPR68 mediates its action through G proteins that stimulate inositol phosphate (IP) production or Ca²⁺ mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. It also serves as a tumor suppressor in prostate cancer. Mutations in the gene result in amelogenesis imperfecta, hypomaturation type 2A6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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