Thermo Fisher Scientific SFTPB Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:200–1:500

Product Specifications

Product Specific Information

Immunogen sequence:
AWTTSSLACA QGPEFWCQSL EQALQCRALG HCLQEVWGHV GADDLCQECE DIVHILNKMA KEAIFQDTMR KFLEQECNVL PLKLLMPQCN QVLDDYFP

Target Information

Pulmonary surfactant is a complex mixture of phospholipids and proteins secreted from type II alveolar cells. It reduces surface tension at the air-liquid interface, ensuring alveolar stability for normal ventilation.
Four distinct proteins—SP-A, SP-B, SP-C, and SP-D—are isolated from pulmonary surfactant:

• SP-A (28–36 kDa) and SP-D (43 kDa): collagenous carbohydrate-binding proteins
• SP-B (8–9 kDa) and SP-C (4 kDa): non-collagenous hydrophobic proteins

SP-B is expressed in pulmonary adenocarcinomas with acinar, papillary, bronchioloalveolar, and solid growth patterns. Squamous cell and large cell carcinomas of the lung and nonpulmonary adenocarcinomas do not express SP-B.
ProSP-B is glycosylated in the Golgi apparatus and undergoes carboxy- and amino-terminal proteolysis by a cathepsin D-like protease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.