Thermo Fisher Scientific CD11b Monoclonal Antibody (CC126), FITC
Bovine CD11b 항원을 인식하는 Mouse monoclonal antibody(CC126)로, FITC 형광 표지되어 Flow Cytometry에 적합합니다. Protein A로 정제되었으며 PBS/BSA buffer에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications
- Flow Cytometry (Flow): Tested Dilution 1:10
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CC126 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745237 |
Additional Formats
- Unconjugated (MA5-28275)
- Request custom conjugation
Product Specific Information
Mouse anti-Bovine CD11b antibody, clone CC126 recognizes the bovine CD11b cell surface antigen.
Target Information
CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that forms a heterodimeric complex with integrin beta-2 (CD18), known as integrin alpha-M beta-2, Mac-1, or CR3 (complement receptor 3).
It is expressed on monocytes/macrophages, granulocytes, activated lymphocytes, subsets of NK cells and dendritic cells, and microglia in the brain.
CD11b/CD18 functions as a receptor for ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X, playing critical roles in cell-cell and cell-matrix interactions.
CD11b expression varies across tissues and cell types, increasing during monocyte maturation and serving as a microglial marker in nervous tissue.
Dysfunction of CD11b is associated with diseases such as systemic lupus erythematosus and ITGAM-related susceptibility to autoimmune conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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