Thermo Fisher Scientific SOCS1 Polyclonal Antibody
SOCS1 단백질을 표적으로 하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체. 인간 및 생쥐 반응성, IHC, ICC/IF, Flow Cytometry 등 다양한 응용 가능. 액상 형태로 제공되며 0.5 mg/mL 농도, TBS 버퍼에 보관. 연구용으로만 사용.
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Thermo Fisher Scientific SOCS1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–10 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | 10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (VLRDYLSSFPFQI) corresponding to C-terminus amino acids of SOCS1 (aa 199–211) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10984104 |
Product Specific Information
- Predicted to react with bovine, canine, and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 1:4000.
Target Information
The Suppressor of Cytokine Signaling (SOCS) and cytokine-inducible SH2 proteins are intracellular regulators of immune responses to cytokines.
SOCS1 suppresses dendritic cell and T-cell hyperactivation by inhibiting JAK tyrosine kinase activity, essential for cytokine receptor signaling.
It also functions as an E3 ubiquitin ligase, mediating polyubiquitination and degradation of target proteins, thereby negatively regulating TLR2 and TLR4 signaling through TIRAP degradation.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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