Thermo Fisher Scientific RAPGEF2 Polyclonal Antibody

Thermo Fisher Scientific RAPGEF2 Polyclonal Antibody

Applications and Tested Dilution

• Western Blot (WB): 1:2,000

Product Specifications

Target Information

Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long-term melanogenesis by reducing dendrite extension and melanin synthesis. Provides inhibitory signals for melanoma cell proliferation and promotes apoptosis in a cAMP-independent manner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway independent of both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and formation of major forebrain fiber connections during brain development. Plays a role in NGF-induced sustained activation of Rap1 at late endosomes and BDNF-induced axon outgrowth of hippocampal neurons. Also involved in regulation of embryonic blood vessel formation and endothelial barrier function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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