Thermo Fisher Scientific ACVRL1 Monoclonal Antibody (2C12)
인간 ACVRL1 단백질을 인식하는 Mouse 모노클로날 항체. Western blot과 ELISA에 사용 가능. 높은 특이성과 재현성을 제공하며, 연구용으로 적합. ACVRL1 관련 질환 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 1–5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2C12 |
| Immunogen | ACVRL1 (AAH42637, 22 a.a. approximately 119 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
DPVKPSRGPL VTCTCESPHC KGPTCRGAWC TVVLVREEGR HPQEHRGCGN LHRELCRGRP TEFVNHYCCD SHLCNHNVSL VLEATQPPSE QPGTDGQL
Target Information
Activin A receptor type II-like 1 (ACVRL1) is a type I cell-surface receptor for the TGF-beta superfamily of ligands.
ACVRL1, similar to other type 1 receptors, has a conserved serine-threonine kinase subdomain, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail.
Mutations in ACVRL1 are associated with hemorrhagic telangiectasia type 2.
Mutations in ACVRL1 have also been linked to Fibrodysplasia Ossificans Progressiva (FOP), a rare genetic disorder characterized by ectopic bone formation, as well as Epicanthus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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