Thermo Fisher Scientific Sortilin (extracellular) Polyclonal Antibody
Rabbit polyclonal antibody targeting extracellular Sortilin for WB and IHC(F) applications. Lyophilized form, reconstitute with 50 µL deionized water. Storage at -20°C. Useful for studying protein transport and neuronal apoptosis mechanisms.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:400–1:500 | - |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-Dependent | - |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide DKDTTRRIHVSTDQD(C) corresponding to amino acid residues 320–335 of human Sortilin |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.4 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2736646 |
Product Specific Information
Product is shipped at room temperature as a lyophilized powder and should be stored at -20°C upon receipt.
Reconstitution: add 50 µL of deionized water.
Target Information
Sortilin functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface.
It is required for protein transport from the Golgi apparatus to lysosomes by a pathway independent of the mannose-6-phosphate receptor (M6PR), and also for transport to endosomes.
Sortilin promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB).
Additionally, Sortilin acts as a receptor for neurotensin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: PA5-77535_Sortilin_Q99523-1_Rabbit.svg, PA5-77535_Sortilin_Q99523-1_Rabbit_PDP.jpeg)
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