Thermo Fisher Scientific CD178 Polyclonal Antibody
CD178(Fas Ligand) 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. WB, IHC, ICC/IF 등 다양한 응용 가능. Human 및 Mouse 반응성, 고순도 친화 크로마토그래피 정제. FasR 결합을 통해 세포자멸사 연구에 적합.
- 카탈로그번호
- PA5104207
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD178 Polyclonal Antibody
Thermo Fisher Scientific CD178 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human FASLG (Accession P48023), corresponding to amino acid residues S117–G167 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853535 |
Product Specific Information
Antibody detects endogenous levels of total Fas Ligand.
Target Information
CD178 (Fas ligand, FasL) is a type-II membrane protein with its N-terminus in the cytoplasm and C-terminal region extending into the extracellular space. Its receptor, FasR, is a cell-surface type-I membrane protein and a member of the tumor necrosis factor (TNF) and nerve growth factor (NGF) receptor family.
As a member of the TNF-cytokine family, CD178 induces apoptosis when interacting with FasR. It may exist as membrane-bound (45 kD) or soluble (26 kD) forms, with the soluble form released upon cleavage by metalloproteinases.
Binding of CD178 to Fas leads to receptor oligomerization and triggers apoptotic cell death through interaction with other proteins. CD178 is predominantly expressed in activated T-lymphocytes and natural killer (NK) cells, and also in immune-privileged tissues such as testis and eye.
Expression has been reported in thymus, liver, ovary, lung, heart, and kidney. Induction of apoptosis through CD178 is mainly involved in anti-viral immune responses.
The Fas/CD178 system plays a role in various human diseases, including AIDS, hepatitis, cancer, atherosclerosis, and inflammatory conditions related to hypertension.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
제품 이미지
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.