Thermo Fisher Scientific Prostaglandin E Receptor EP2 Polyclonal Antibody
Prostaglandin E Receptor EP2 폴리클로날 항체로, Human 및 Mouse에 반응합니다. Western blot, IHC, ICC/IF, ELISA 등 다양한 응용에 적합하며, Rabbit IgG 호스트 기반으로 제작되었습니다. Affinity chromatography로 정제된 액상 형태로, 연구용으로만 사용됩니다.
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Thermo Fisher Scientific Prostaglandin E Receptor EP2 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| Immunocytochemistry (ICC/IF) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
| Immunomicroscopy (IM) | 1:50–1:200 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 300–350 on human Prostaglandin E2 receptor EP3 subtype |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Prostaglandins are produced by the metabolism of arachidonic acid. Prostaglandin E2 is one of the five physiologically significant prostanoids known. Its wide spectrum of physiologic and pharmacologic effects in various tissues is mediated through binding to the Prostaglandin E2 receptors (EP1, EP2, EP3, and EP4). These include effects on the immune, endocrine, cardiovascular, renal, and reproductive systems as well as smooth muscle.
Prostaglandin E2 is abundant in the brain, where it plays an important role in neural functions, particularly in newborns, and acts as a mediator of inflammation. PGE-2 signals through G-protein coupled EP receptors, which have four subtypes: EP1, EP2, EP3, and EP4. EP2 receptors are 358 amino acid proteins with a short third intracellular loop. They stimulate adenylyl cyclase via coupling to Gs and do not undergo PGE-2-induced internalization. EP2 receptors are involved in smooth muscle contraction and relaxation and are mainly localized in lung and placental tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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