Thermo Fisher Scientific IDH1 Monoclonal Antibody (OTI3G9), TrueMAB
IDH1 R132H 변이 단백질을 인식하는 마우스 단일클론 항체로, Western blot 및 IHC(P) 적용 가능. 고순도 친화 크로마토그래피 정제, 1 mg/mL 농도. PBS/BSA/glycerol 버퍼에 보관, 연구용으로 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3G9 |
| Immunogen | Synthetic peptide around the R132H mutation region of human IDH1 conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Isocitrate dehydrogenases such as IDH1 catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one utilizing NAD(+) and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent forms localized to the mitochondrial matrix, and two NADP(+)-dependent forms, one mitochondrial and one cytosolic. The NADP(+)-dependent isozyme is a homodimer. The IDH1 protein is the cytoplasmic and peroxisomal NADP(+)-dependent isocitrate dehydrogenase containing a PTS-1 peroxisomal targeting signal. Its presence in peroxisomes suggests roles in NADPH regeneration for intraperoxisomal reductions and in reactions consuming 2-oxoglutarate. The cytoplasmic enzyme plays a key role in NADPH production. This antibody is specific for IDH1 (mutant R132H).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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