Thermo Fisher Scientific MED28 Monoclonal Antibody (OTI10C8)
MED28 단백질을 인식하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody (Clone OTI10C8). Western blot 및 IHC(Paraffin) 분석에 적합하며, 고순도 Affinity Chromatography로 정제. 인간 시료 반응성, 액상 형태로 안정적인 저장 가능.
- 카탈로그번호
- MA527256
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific MED28 Monoclonal Antibody (OTI10C8)
Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI10C8 |
| Immunogen | Full length human recombinant protein of MED28 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2724667 |
Target Information
The mediator complex is a multi-protein transcriptional co-activator expressed ubiquitously in eukaryotes from yeast to mammals. It is required for induction of RNA polymerase II transcription by DNA-binding transcription factors.
MED28 (also known as Magicin) is one of the proteins in this complex and is expressed in many cell lines and tissues. Down-regulation of MED28 in NIH3T3 cells induces genes associated with smooth muscle cell differentiation, while overexpression represses SMC gene expression.
MED28 can form a ternary complex with Grb2 and Merlin (the neurofibromatosis 2 tumor suppressor protein), suggesting a role in Merlin’s tumor suppressive activity. It has also been identified as an HIV dependency factor (HDF), making it a potential drug target in HIV treatment.
At least two isoforms of MED28 are known to exist.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
제품 이미지
(이미지 없음)
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.