Thermo Fisher Scientific ADSL Polyclonal Antibody
ADSL 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western Blot, ICC/IF, IP에 사용 가능. 고순도(>95%)로 정제된 액상 형태이며, 단기 4°C 보관 및 장기 -20°C 보관 권장. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
- Publications: 없음
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:50–1:200
- Publications: 없음
Immunoprecipitation (IP)
- Tested Dilution: 1:50–1:100
- Publications: 없음
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length Human ADSL |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720626 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. The purity is >95% (by SDS-PAGE).
Target Information
ADSL (adenylosuccinate lyase), also known as AMPS, ASL or ASASE, is a 484 amino acid protein involved in purine biosynthesis and AMP formation from inosine monophosphate.
Expressed ubiquitously, ADSL catalyzes two key reactions in AMP biosynthesis:
- Removal of fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to yield aminoimidazole carboxamide ribotide (AICA)
- Removal of fumarate from adenylosuccinate to yield AMP
Defects in the ADSL gene cause adenylosuccinase deficiency, an autosomal recessive disorder characterized by epilepsy, growth retardation, and muscular wasting. Multiple isoforms of ADSL exist due to alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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