Thermo Fisher Scientific FIS1 Monoclonal Antibody (1G9)
FIS1 단백질을 표적으로 하는 Thermo Fisher Scientific의 단클론 항체(1G9). Western blot, IHC, ELISA에 적합하며 인간 시료 반응성. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공. 미토콘드리아 분열 및 아폽토시스 연구용에 적합.
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Thermo Fisher Scientific FIS1 Monoclonal Antibody (1G9)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3 µg/mL |
| ELISA | 1 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1G9 |
| Immunogen | FIS1 (AAH03540.1, 1–152 a.a) full-length recombinant protein with GST tag (MW of GST tag: 26 KDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MEAVLNELVS VEDLLKFEKK FQSEKAAGSV SKSTQFEYAW CLVRSKYNDD IRKGIVLLEE LLPKGSKEEQ RDYVFYLAVG NYRLKEYEKA LKYVRGLLQT EPQNNQAKEL ERLIDKAMKK DGLVGMAIVG GMALGVAGLA GLIGLAVSKS KS
Target Information
Fis1 is a 17 kDa integral membrane protein and a component of the mitochondrial fission machinery. It includes a central leucine-zipper domain, coiled-coil region, tetratricopeptide repeat domain, and a C-terminal transmembrane domain. Fis1 acts as a pro-apoptotic factor, regulating mitochondrial fission and interacting with DLP1 and Mdv1p to facilitate Dnm1p recruitment to the fission complex. It also plays a role in peroxisome growth and division. Loss of Fis1 inhibits apoptosis and leads to mitochondrial elongation.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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