Thermo Fisher Scientific CD122 Polyclonal Antibody
CD122(IL-2Rβ) 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody입니다. WB, IHC, ICC/IF에 사용 가능하며, 인간 및 생쥐 시료 반응성이 있습니다. 액상 형태로 제공되며, 고순도 친화 크로마토그래피로 정제되었습니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human IL2RB (Accession P14784), corresponding to amino acid residues W70–A120 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818331 |
Product Specific Information
Antibody detects endogenous levels of total IL-2R beta/CD122.
Target Information
CD122 (Interleukin 2 receptor beta) is involved in T cell-mediated immune responses, primarily expressed in the hematopoietic system and exists in three forms:
- Low affinity form: alpha subunit monomer, not involved in signal transduction
- Intermediate affinity form: alpha/beta heterodimer
- High affinity form: alpha/beta/gamma heterotrimer
Both the intermediate and high affinity forms participate in receptor-mediated endocytosis and mitogenic signal transduction. The CD122 gene encodes the beta subunit, a type I membrane protein.
Dysfunction of CD122 is associated with oligoarticular juvenile idiopathic arthritis and rheumatoid factor negative juvenile idiopathic arthritis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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