Thermo Fisher Scientific ERBB3 Monoclonal Antibody (2C7)
ERBB3 단백질을 표적으로 하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody (Clone 2C7). IHC 및 ELISA에 적합하며, 인간 시료에 반응. 고순도 친화 크로마토그래피 정제, PBS 버퍼 저장, 연구용 전용.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1.2 µg/mL
ELISA
- Tested Dilution: 0.3 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2C7 |
| Immunogen | ERBB3 (AAH02706, 21 a.a. approximately 331 a.a) full-length recombinant protein with GST tag (MW of GST tag alone: 26 KDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
EVGNSQAVCP GTLNGLSVTG DAENQYQTLY KLYERCEVVM GNLEIVLTGH NADLSFLQWI REVTGYVLVA MNEFSTLPLP NLRVVRGTQV YDGKFAIFVM LNYNTNSSHA LRQLRLTQLT EILSGGVYIE KNDKLCHMDT IDWRDIVRDR DAEIVVKDNG RSCPPCHEVC KGRCWGPGSE DCQTLTKTIC APQCNGHCFG PNPNQCCHDE CAGGCSGPQD TDCFACRHFN DSGACVPRCP QPLVYNKLTF QLEPNPHTKY QYGGVCVASC PHNFVVDQTS CVRACPPDKM EVDKNGLKMC EPCGGLCPKA F
Target Information
ErbB3 (c-erbB-3/HER-3) is a member of the type I family of growth factor receptors and binds to ligands in the heregulin family.
ErbB3 is over-expressed in various tumors including prostate, bladder, breast, stomach, pancreas, and colon.
Heregulin and EGF stimulate tyrosine phosphorylation of c-erbB-3 to different extents.
The ErbB3 gene is located on the long arm of human chromosome 12 (12q13) and encodes a 160/180 kDa glycoprotein.
It forms heterodimers with other EGF receptor family members, leading to activation of pathways for cell proliferation or differentiation.
Alternate splice variants exist, including a secreted isoform that modulates membrane-bound receptor activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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