Thermo Fisher Scientific Phospho-TPH1 (Ser260) Polyclonal Antibody
인간 Tryptophan Hydroxylase의 Ser260 인산화 부위를 인식하는 Rabbit Polyclonal Antibody입니다. Western blot 및 IHC(P) 분석에 적합하며, 비결합형 액상 형태로 제공됩니다. 1 mg/mL 농도로 -20°C에 보관하며 연구용으로만 사용됩니다.
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Thermo Fisher Scientific Phospho-TPH1 (Ser260) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human Tryptophan Hydroxylase around the phosphorylation site of Ser260 (H-S-SP-D-P) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555133 |
Target Information
Tryptophan hydroxylase (TPH) catalyzes the 5-hydroxylation of tryptophan, which is the first step in the biosynthesis of indoleamines such as serotonin and melatonin (Martinez et al., 2001).
In mammals, serotonin biosynthesis occurs predominantly in neurons originating from the Raphe nuclei of the brain, while melatonin synthesis takes place in the pineal gland.
TPH activity is rate-limiting for serotonin but not melatonin biosynthesis. Serotonin acts mainly as a neurotransmitter, whereas melatonin is the principal hormone secreted by the pineal gland.
The activity of TPH is enhanced by phosphorylation through cAMP-dependent protein kinase (PKA) and Ca²⁺/calmodulin kinase II (CAM K II) (Jiang et al., 2000; Johansen et al., 1996).
Both PKA and CAM K II phosphorylate Ser58 within the regulatory domain of TPH (Kuhn et al., 1997).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: PA5-38534_TPH1_P17752-1_Rabbit.svg)
(이미지: PA5-38534_TPH1_P17752-1_Rabbit_PDP.jpeg)
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