Thermo Fisher Scientific PD-L1 Monoclonal Antibody (OTI16H9), TrueMAB
PD-L1 단백질을 인식하는 mouse monoclonal antibody (OTI16H9). Western blot에 적합하며, 인간 시료에 반응. Lyophilized 형태로 제공되며, 재구성 후 약 1 mg/mL 농도. 종양 면역 회피 연구에 유용.
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Applications
- Western Blot (WB): 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI16H9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 19–290 of human CD274 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Programmed death receptor ligand 1 (PD-L1, also known as B7-H1) is a B7 family member that binds to programmed death receptor 1 (PD-1), a negative regulator of T-cell receptor (TCR) signaling.
Upon PD-1 ligation, PD-L1 reduces TCR-mediated proliferation and cytokine production. PD-L1 is abundantly expressed in many human and murine cancers and can be upregulated by IFN-γ stimulation, indicating its potential role in tumor immune evasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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