Thermo Fisher Scientific BIN1 Polyclonal Antibody, MaxPab

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000

Immunocytochemistry (ICC/IF)

• Tested Concentration: 30 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MAEMGSKGVT AGKIASNVQK KLTRAQEKVL QKLGKADETK DEQFEQCVQN FNKQLTEGTR LQKDLRTYLA SVKAMHEASK KLNECLQEVY EPDWPGRDEA NKIAENNDLL WMDYHQKLVD QALLTMDTYL GQFPDIKSRI AKRGRKLVDY DSARHHYESL QTAKKKDEAK IAKAEEELIK AQKVFEEMNV DLQEELPSLW NSRVGFYVNT FQSIAGLEEN FHKEMSKLNQ NLNDVLVGLE KQHGSNTFTV KAQPSDNAPA KGNKSPSPPD GSPAATPEIR VNHEPEPAGG ATPGATLPKS PSQLRKGPPV PPPPKHTPSK EVKQEQILSL FEDTFVPEIS VTTPSQPAEA SEVAGGTQPA AGAQEPGETA ASEAASSSLP AVVVETFPAT VNGTVEGGSG AGRLDLPPGF MFKVQAQHDY TATDTDELQL KAGDVVLVIP FQNPEEQDEG WLMGVKESDW NQHKELEKCR GVFPENFTER VP

Target Information

This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일: H00000274-D01P_BIN1_O00499-1_Rabbit.svg, H00000274-D01P_BIN1_O00499-1_Rabbit_PDP.jpeg)