Thermo Fisher Scientific HLA-DRA Monoclonal Antibody (302CT2.3.2)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:100

-

Product Specifications

Host/Isotype

Mouse / IgM, kappa

Class

Monoclonal

Type

Antibody

Clone

302CT2.3.2

Immunogen

KLH conjugated synthetic peptide between 48-75 amino acids from human HLA-DRA if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:HLA-DRA,uniProtId:P01903-1,ncbiNodeId:9606,antigenRange:48-75,antigenLength:254,antigenImageFileName:MA5-37529_HLA-DRA_P01903-1_House_mouse.svg,antigenImageFileNamePDP:MA5-37529_HLA-DRA_P01903-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Lot-Specific

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

Target Information

HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.

HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.