Thermo Fisher Scientific SLC22A17 Polyclonal Antibody
SLC22A17 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC, ICC/IF, ELISA 등에 사용 가능. Human 종에 반응하며, Protein G로 정제된 1 mg/mL 액상 형태. PBS/glycerol buffer에 보관하며, 연구용으로 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:500 |
| ELISA | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human Solute Carrier Family 22 Member 17 protein (1–99AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.03% ProClin 300 |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_2813262 |
Target Information
The SLC22 family of organic anion and cation transporters (OATs, OCTs, OCTNs) are transmembrane proteins predominantly expressed in kidney and liver. Each contains 12 predicted alpha-helical transmembrane domains (TMDs) and one large extracellular loop between TMDs 1 and 2.
These transporters function as:
- Uniporters mediating facilitated diffusion (OCTs)
- Anion exchangers (OAT1, OAT3, URAT1)
- Na(+)/L-carnitine cotransporter (OCTN2)
SLC22 family members are involved in the absorption and excretion of drugs, xenobiotics, and endogenous compounds, contributing to homeostasis in various organs.
Mutations in this family are linked to diseases such as primary systemic carnitine deficiency and idiopathic renal hypouricemia, and can affect drug absorption or excretion.
SLC22A17, acting as a receptor for Lipocalin 2, shows relatively high expression in hematopoietic stem cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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