Thermo Fisher Scientific SLC22A17 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

The SLC22 family of organic anion and cation transporters (OATs, OCTs, OCTNs) are transmembrane proteins predominantly expressed in kidney and liver. Each contains 12 predicted alpha-helical transmembrane domains (TMDs) and one large extracellular loop between TMDs 1 and 2.

These transporters function as:

• Uniporters mediating facilitated diffusion (OCTs)
• Anion exchangers (OAT1, OAT3, URAT1)
• Na(+)/L-carnitine cotransporter (OCTN2)

SLC22 family members are involved in the absorption and excretion of drugs, xenobiotics, and endogenous compounds, contributing to homeostasis in various organs.
Mutations in this family are linked to diseases such as primary systemic carnitine deficiency and idiopathic renal hypouricemia, and can affect drug absorption or excretion.

SLC22A17, acting as a receptor for Lipocalin 2, shows relatively high expression in hematopoietic stem cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.