Thermo Fisher Scientific MASP2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total MASP2.

Target Information

Mannose (or mannan)-binding lectin (MBL), also known as serum mannose-binding protein (MBP), initiates the lectin branch of the innate immune response by binding to the surface of potentially pathogenic microorganisms and initiating complement fixation through an N-terminal collagen-like domain.
MBL is a key component in immune response as it can directly trigger neutralization of invading microorganisms by an antibody-independent mechanism.
Mutations of human MBL are associated with immunodeficiency resulting from reduced ability to initiate complement fixation.
In humans, three types of MBL-associated serine proteases—MASP-1, MASP-2, and MASP-3—and a truncated form of MASP-2 (sMAP or MAp19) complex with MBL to activate the lectin pathway of the complement system.
Activated MASPs subsequently cleave and activate downstream components of the complement pathway.
MASP-3 is an alternatively spliced product from the MASP-1 gene and may inhibit MASP-2 by competing for MBL binding.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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