Thermo Fisher Scientific RNF111 Polyclonal Antibody
RNF111 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot에 적합하며, TGF-β/NODAL 신호 경로 연구에 활용 가능. 액상 형태, 1 mg/mL 농도, -20°C 보관.
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Thermo Fisher Scientific RNF111 Polyclonal Antibody
Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide derived from the C-terminal region of human RNF111 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555736 |
Target Information
The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF)-beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription.
As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development.
Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
[provided by RefSeq, Jul 2012]
Usage Notice
For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.
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