Thermo Fisher Scientific Mtp53 (N235K,N239Y) Polyclonal Antibody
Mtp53(N235K,N239Y) 변이형을 인식하는 Rabbit Polyclonal 항체로, Human 및 Mouse 시료에 반응합니다. IHC, ICC, Flow Cytometry, ELISA 등 다양한 응용에 사용 가능하며, Protein A로 정제된 고순도 제품입니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human Mtp53 around N235K and N239Y |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nutrient deprivation. p53 activation leads to the transcription of genes such as p21waf1, promoting G1 or G2/M arrest.
p53 consists of:
- N-terminal transactivation domain
- Central DNA-binding domain
- Oligomerization domain
- C-terminal regulatory domain
Phosphorylation at Ser15 is crucial for activation and stabilization, while Ser392 phosphorylation is associated with tumor formation. p53 plays a key role in preventing proliferation of damaged cells and functions as an anticancer agent. Mutations in the TP53 gene, such as those seen in Li-Fraumeni syndrome, can lead to loss of tumor suppressor activity and contribute to malignancy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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