Thermo Fisher Scientific Collagen 17 Monoclonal Antibody (1C11)
Rabbit monoclonal antibody targeting human Collagen XVII (COL17A1). Suitable for Western blot and IHC applications. Provides high specificity and reproducibility. Supplied as unconjugated liquid form at 1 mg/mL, stored at -20°C.
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Applications
Western Blot (WB)
- Tested Dilution: 1:300–1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1C11 |
| Immunogen | Recombinant human Collagen XVII protein (approx. 1300–1450 aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
Target Information
COL17A1 is the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein and a structural component of hemidesmosomes—multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane.
COL17A1 belongs to the FACIT collagen family (fibril-associated collagens with interrupted helices). It is localized to tissues containing type I collagen and may help maintain extracellular matrix integrity.
Diseases associated with COL17A1 dysfunction include epithelial recurrent erosion dystrophy and epidermolysis bullosa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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