Thermo Fisher Scientific TNFSF11 Monoclonal Antibody (8C1)

Thermo Fisher Scientific TNFSF11 Monoclonal Antibody (8C1)

Applications

• ELISA (ELISA)

Tested Dilution: 10 µg/mL
Publications: -

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
SKLEAQPFAH LTINATDIPS GSHKVSLSSW YHDRGWGKIS NMTFSNGKLI VNQDGFYYLY ANICFRHHET SGDLATEYLQ LMVYVTKTSI KIPSSHTLMK GGSTKYWSGN SEFHFYSINV GGFFKLRSGE EISIEVSNPS LLDPDQDATY FGAFKVRDID

Target Information

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family, which acts as a ligand for osteoprotegerin and is a key factor for osteoclast differentiation and activation. It functions as a dendritic cell survival factor and regulates T cell-dependent immune responses.
T cell activation induces expression of this gene, leading to increased osteoclastogenesis and bone loss. This protein activates antiapoptotic kinase AKT/PKB via a signaling complex involving SRC kinase and TRAF6, suggesting a role in cell apoptosis regulation.
Gene disruption in mice results in severe osteopetrosis, lack of osteoclasts, and defects in T/B lymphocyte differentiation and mammary structure formation during pregnancy. Two alternatively spliced transcript variants have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.