Thermo Fisher Scientific ZMIZ2 Polyclonal Antibody
인간 ZMIZ2 단백질을 인식하는 rabbit polyclonal 항체로, IHC(P) 및 ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS 기반 버퍼에 40% 글리세롤 포함. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ZMIZ2. Recombinant protein control fragment (Product # RP-89718) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2649937 |
Product Specific Information
Immunogen sequence:
LMPSVMEMIA ALGPGAAPFA PLQPPSVPAP SDYPGQGSSF LGPGTFPESF PPTTPSTPTL AEFTPGPPPI SYQSDIPSSL LTSEKSTACL PSQMAPAGHL DPTHNPGTPG LHTSNL
Highest antigen sequence identity to the following orthologs:
- Mouse: 85%
- Rat: 85%
Target Information
ZIMP7, also known as ZMIZ2, is a novel PIAS (protein inhibitor of activated signal transducer and activator of transcription)-like protein and a transcriptional coactivator.
ZIMP7 is expressed most abundantly in testis. The C-terminal proline-rich domain possesses significant intrinsic transcriptional activity, which is inhibited by the N-terminus in the full-length ZIMP7.
ZIMP7 and the related protein ZIMP10 interact with PIAS3 and enhance Androgen Receptor (AR)-mediated transcription.
The interaction between ZIMP7 and the SWI/SNF complex suggests a possible role for ZIMP7 in chromatin modification.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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