Thermo Fisher Scientific VAMP4 Polyclonal Antibody
Rabbit polyclonal antibody targeting VAMP4 protein for WB and IHC applications. Reactive with human, mouse, rat, and non-human primate samples. Lyophilized form for long-term stability at -20°C. Suitable for vesicle membrane fusion studies and SNARE co...
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10–50 µg/mL | - |
| Immunohistochemistry (IHC) | 10–50 µg/mL | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from mouse VAMP4 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: VAMP4.
Target Information
The vesicle associated membrane proteins (VAMP) or synaptobrevins are calcium-binding proteins specific to eukaryotes. VAMPs, together with synaptosomal associated protein of 25 kDa (SNAP-25) and syntaxin, form the core complex of soluble NSF attachment protein receptor (SNARE) proteins that interact with soluble proteins N-ethylmaleimide-sensitive factor (NSF) and alpha-SNAP. These membrane-associated proteins play a key role in regulating vesicle membrane fusion with the plasma membrane. The Clostridium tetani neurotoxin is a metalloprotease specific for VAMP. In Alzheimer’s disease, VAMP levels of all isoforms appear to be significantly lowered.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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