Thermo Fisher Scientific Argonaute 3 Polyclonal Antibody
Human Argonaute 3 단백질에 특이적인 Rabbit Polyclonal Antibody로, IHC(P) 등 다양한 응용 가능. 항원 친화 크로마토그래피로 정제되었으며, 높은 종간 반응성 보유. 연구용 RNAi 및 miRNA 관련 단백질 분석에 적합.
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:20–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human Argonaute 3. Recombinant protein control fragment (Product #RP-100945). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2638128 |
Product Specific Information
- Immunogen sequence: WHLLHEVLTG RTLPEPLELD KPISTNPVHA VDVVLRHLP
- Highest antigen sequence identity to the following orthologs:
- Mouse: 90%
- Rat: 100%
Target Information
AGO3 (Argonaute-3) is required for RNA-mediated gene silencing (RNAi). It binds short RNAs such as microRNAs (miRNAs) and represses translation of complementary mRNAs.
AGO3 is proposed to stabilize small RNA derivatives (riRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells.
It also contributes to riRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting an mRNA decapping complex involving EDC4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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