Thermo Fisher Scientific Argonaute 3 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human Argonaut 3. Recombinant protein control fragment (Product #RP-100945). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Argonaute 3,uniProtId:Q9H9G7-1,ncbiNodeId:9606,antigenRange:133-171,antigenLength:860,antigenImageFileName:PA5-61716_Argonaute_3_Q9H9G7-1_Rabbit.svg,antigenImageFileNamePDP:PA5-61716_Argonaute_3_Q9H9G7-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2638128

Product Specific Information

Immunogen sequence: WHLLHEVLTG RTLPEPLELD KPISTNPVHA VDVVLRHLP

Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 100%.

Target Information

AGO3 (protein argonaute-3) is required to RNA-mediated gene silencing (RNAi). It binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. AGO3 is proposed to be involved in stabilization of small RNA derivates (riRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent riRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.