Thermo Fisher Scientific CD16/FcgammaReceptor III Monoclonal Antibody (HO-80)
인간 CD16/Fcgamma Receptor III 인식용 Mouse 단클론 항체(HO-80). ICC/IF, Flow Cytometry, Functional Assay에 최적화. 단백질 A/G 정제, PBS buffer에 보존, 무보존제. 연구용 전용 제품.
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Thermo Fisher Scientific CD16/FcgammaReceptor III Monoclonal Antibody (HO-80)
Applications 및 Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
| Functional Assay (Functional) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HO-80 |
| Immunogen | PBLs from a NK-leukemia patient |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD16 encodes a receptor that recognizes the Fc portion of immunoglobulin G and is involved in the clearance of immune complexes from the circulation, as well as other functions such as cellular mediated cytotoxicity and enhancement of virus infections.
This gene, FCGR3A, shares a high degree of similarity with another nearby gene, FCGR3B, located on chromosome 1.
Expression:
- FCGR3A: Natural Killer (NK) cells, integral membrane glycoprotein anchored through a transmembrane peptide
- FCGR3B: Polymorphonuclear neutrophils (PMN), anchored through a phosphatidylinositol (PI) linkage
Clinical relevance:
Mutations in this gene have been associated with Immunodeficiency 20 and linked to susceptibility to recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia.
Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Diseases associated: Immunodeficiency 20, Herpes Zoster
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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