Thermo Fisher Scientific Neurogenin 1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:100

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human NEUROG1(Accession Q92886), corresponding to amino acid residues A137-G187. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Neurogenin 1,uniProtId:Q92886-1,ncbiNodeId:9606,antigenRange:137-187,antigenLength:237,antigenImageFileName:PA5-102697_Neurogenin_1_Q92886-1_Rabbit.svg,antigenImageFileNamePDP:PA5-102697_Neurogenin_1_Q92886-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2852091

Product Specific Information

Antibody detects endogenous levels of total NEUROG1.

Target Information

Neurogenin 1 is a basic helix-loop-helix (bHLH) proteins are transcription factors involved in determining cell type during development. NeuroG1 is a bHLH protein with dual cell-fate specification roles. It functions during neurogenesis, and it has also been shown to inhibit the differentiation of neural stem cells into astrocytes. NeuroG1 promotes neurogenesis by functioning as a transcriptional activator, yet it inhibits astrocyte differentiation by compartmentalizing the CREB-binding protein transcription complex away from astrocyte differentiation genes and by inhibiting STAT transcription factors essential for gliogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.