Thermo Fisher Scientific HINT1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Immunogen sequence:
IPKKHISQIS VAEDDDESLL GHLMIVGKKC AADLGLNKGY RMVVNEGSDG GQSVYHVHLH VL

Highest antigen sequence identity:
Mouse – 92%, Rat – 92%

Target Information

Histidine triad nucleotide-binding protein 1 (HINT1) is a member of the histidine triad (HIT) protein family, a group of small nucleotide-binding and -hydrolyzing proteins. HINT1 interacts with several diverse proteins and has been suggested to have tumor suppressive activities. HINT1 catalyzes the hydrolysis of adenosine 5'-monophoramidate substrates such as AMP-morpholidate, but its enzymatic function does not appear to play a role in its tumor suppression. Recent experiments demonstrate that HINT1 forms a complex with POSH and JNK in vivo, inhibiting AP-1 activity and the phosphorylation of c-Jun, which may contribute to the tumor suppressor activity of HINT1. Other studies raise the possibility of HINT1 as a candidate gene for schizophrenia.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.